2'-Deoxyuridine

2'-Deoxyuridine

CAS No 951-78-0
Formula C9H12N2O5
Application

White or almost white crystalline powder

Loss on drying ≤0.5%

Residue on ignition ≤0.2%

Assay(HPLC) ≥99%


An uridine derivative as therapeutic agent for treating allergy, cancer, infection and autoimmune disease


2'-Deoxyuridine is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms.

Derivatized 2'-Deoxyuridines used as labeling substrates include chloro-2'-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogues of 2'-deoxyuridine include 5-ethynyl-2'-deoxyuridine (DdU) and 5-hydroxymethyl-2'-deoxyuridine (HmdU).

Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies.

Deoxyuridine (dU) is used to indirectly determine if there are sufficient levels of folate and cobalamin in cell or tissue samples.


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