Altiratinib

Altiratinib (dcc-2701) is an effective inhibitor of Trk, met (c-met), Tie2 and VEGFR2 kinase. The IC50 for TrkA, B and C are 0.9 nm, 4.6 nm and 0.8 nm, respectively. It inhibits met (c-met) and met (c-met) mutants with an IC50 range of 0.3-6 nm.